Background
VEGF-C,amemberoftheVEGF/PDGFfamilyofstructurallyrelatedproteins,isapotentangiogeniccytokine.Itpromotesendothelialcellgrowth,promoteslymphangiogesis,andcanalsoaffectvascularpermeABIlity.VEGF-Cisexpressedinvarioustissues,butisnotproducedinperipheralbloodlymphocytes.Itformscellsurfaced-associatednon-covalentdisulfidelinkedhomodimers,andcanbindandactivatebothVEGFR-2(flk1)andVEGFR-3(flt4)receptors.Duringembryogenesis,VEGF-Cmayplayaroleintheformationofthevenousandlymphaticvascularsystems.BothVEGF-CandVEGF-Dareover-expressedincertaincancers,andtheresultingelevatedlevelsofVEGF-CorVEGF-Dtendtocorrelatewithincreasedlymphaticmetastasis.RecombinanthumanVEGF-Cisa13.5kDanon-disulfidelinkedhomodimericproteinconsistingoftwo116aminoacidpolypeptidechains.Duetoglycosylationtheproteinmigratesasa20.0-22.0kDabandundernon-reducingcondition.
Specifications