Background
ThethreemammalianisoformsofTGF-β,TGF-β1,β2,β3,signalthroughthesamereceptorandelicitsimilarBIOLOGicalresponses.Theyaremultifunctionalcytokinesthatregulatecellproliferation,growth,differentiationandmotilityaswellassynthesisanddepositionoftheextracellularmatrix.Theyareinvolvedinvariousphysiologicalprocessesincludingembryogenesis,tissueremodelingandwoundhealing.Theyaresecretedpredominantlyaslatentcomplexeswhicharestoredatthecellsurfaceandintheextracellularmatrix.ThereleaseofbiologicallyactiveTGF-βisoformfromalatentcomplexinvolvesproteolyticprocessingofthecomplexand/orinductionofconformationalchangesbyproteinssuchasthrombospondin-1.ThephysiologicalroleofTGF-β3isstillunknownbutitsexpressionpatternsuggestsaroleintheregulationofcertaindevelopmentprocesses.RecombinanthumanTGF-β3isa25.0kDaproteincomposedoftwoidentical112aminoacidpolypeptidechainslinkedbyasingledisulfidebond.
Specifications