Background
BothMIP-1alphaandMIP-1betaarestructurallyandfunctionallyrelatedCCchemokines.TheyparticipateinthehostresponsetoinvADIngbacterial,viral,parasiteandfungalpathogensbyregulatingthetraffickingandactivationstateofselectedsubgroupsofinflammatorycellse.g.macrophages,lymphocytesandNKcells.WhilebothMIP-1alphaandMIP-1betaexertsimilareffectsonmonocytestheireffectonlymphocytesdiffer;withMIP-1alphaselectivelyattractingCD8+lymphocytesandMIP-1betaselectivelyattractingCD4+lymphocytes.Additionally,MIP-1alphaandMIP-1betahavealsobeenshowntobepotentchemoattractantsforBcells,eosinophilsanddendriticcells.BothhumanandmurineMIP-1alphaandMIP-1betaareactiveonhumanandmurinehematopoieticcells.RecombinantratMIP-1betaisa7.8kDaproteincontaining69aminoacidresidues,includingthefourhighlyconservedcysteineresiduespresentinCCchemokines.
Specifications