
Background
GLP-1isaproglucagon-derivedpeptidehormonesecretedprimarilybyintestinalLcellsduringfeeding.Itsmajorphysiologicalfunctionisstimulationofpancreaticβ-cellstoreleaseappropriateamountsofinsulinafterglucoseabsorption.OtherBIOLOGicalactionsexhibitedbyGLP-1includesuppressionofplasmaglucagonslevels,inhibitionofgastricmotility,andpromotionofsatiety.ThesecretionofGLP-1fromintestinalLcellsisstimulatedbynutrients,hormones,andneuralinputs.Ontheotherhand,insulinhasbeenreportedtoinhibitGLP-1release,indicatingthatafeedbackloopmechanismregulatesGLP-1secretion.InadditiontobeingtheprecursorofGLP-1,proglucagon,whoseprimarystructureishighlyconservedinmammalianspecies,isalsotheprecursorforothermembersoftheglucagonfamilyofpeptidehormonesincludingglicentin-relatedpancreaticpeptide(GRPP),glucagons,andGLP-2.RecombinanthumanGLP-1isa3.3kDaconsistingof31aminoacidresidues.
Specifications